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Search Results for " EGFR Inhibitor "

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ライブラリー

カタログ番号	製品名	別名	ターゲット
T2705	Mutant EGFR inhibitor		EGFR
	Mutant EGFR inhibitor is a selective and potent Mutated EGFR inhibitor, inhibits L858R activating mutant, the Exonl9 deletion activating mutant and the T790M resistance mutant.		EGFR
T21954	EGFR/ErbB-2/ErbB-4 inhibitor-2	EGFR/ErbB2 Inhibitor	EGFR
	EGFR/ErbB-2/ErbB-4 inhibitor-2 (EGFR/ErbB2 Inhibitor) is a cell-permeable inhibitor of EGFR and c-ErbB2 (IC50s = 20 and 79 nM, respectively)		EGFR
T5168	EGFR-IN-12	EGFR Inhibitor	Apoptosis , EGFR
	EGFR-IN-12 (EGFR Inhibitor) is a cell permeable and selective inhibitor of EGFR kinase (IC50: 21 nM) and blocks receptor autophosphorylation in cells.		Apoptosis , EGFR
T79861	EGFR/ErbB-2 inhibitor-1		EGFR
	EGFR/ErbB-2 inhibitor-1 is a selective ErbB2/HER2 inhibitor that effectively blocks ErbB2 and HER2 signaling.		EGFR
T11160	EGFR-IN-5		EGFR
	EGFR-IN-5 is a EGFR inhibitor, EGFR-IN-5 with IC50s of 10.4, 1.1, 34, 7.2 nM for EGFR, EGFRL858R, EGFRL858R/T790M, and EGFRL858R/T790M/C797S, respectively.		EGFR
T11162	EGFR-IN-8		EGFR , c-Met/HGFR
			EGFR , c-Met/HGFR
T11161	EGFR-IN-7	TQB3804	EGFR
	EGFR-IN-7 (TQB3804) is a selective and potent EGFR kinase inhibitor.		EGFR
T9905	Cetuximab	Cetuximab (anti-EGFR),C225	EGFR
	Cetuximab (C225) is a monoclonal antibody that is an inhibitor of human epidermal growth factor receptor (EGFR) (Kd=0.201 nM). Cetuximab has antitumor activity, inhibiting tumor cell proliferation and inducing apoptosis.		EGFR
TQ0255	Olafertinib	CK-101,EGFR-IN-3,RX-518	EGFR
	Olafertinib (RX-518) is a novel mutant-selective, irreversible, orally available EGFR inhibitor. It can overcome T790M-mediated resistance in NSCLC.		EGFR
T16162	Mutated EGFR-IN-1	Osimertinib analog	EGFR
	Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant, and T790M resistance mutant.		EGFR
T63648	EGFR kinase inhibitor 1
	EGFR kinase inhibitor 1 is a potent inhibitor of EGFR that acts on WT (IC50: 37 nM), l885R/T790M (IC50: 1.7 nM), and L858R/T790M/C797S (IC50>300 nM). EGFR kinase inhibitor 1 is capable of blocking the cell cycle in G0/G1...
T60076	Oritinib	SH-1028	EGFR
	Oritinib (SH-1028) is an inhibitor of EGFR with IC50s of 18, 0.7, 4, 0.1, 1.4 and 0.89 nM for EGFR (wt), EGFR (L858R), EGFR (L861Q), EGFR (L858R/T790M), EGFR (d746-750), EGFR (d746-750/T790M), respectively. Oritinib can ...		EGFR
T9865	Almonertinib mesylate		EGFR
	Almonertinib mesylate is an irreversible inhibitor of EGFR tyrosine kinase with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate can be used in the non-small cell lung cancer st...		EGFR
T9927	Panitumumab		EGFR
	Panitumumab is a fully human IgG2 monoclonal antibody targeting the epidermal growth factor receptor EGFR).		EGFR
T6733	WZ-3146		EGFR
	WZ3146 is a mutant-selective irreversible inhibitor of EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I).		EGFR
T5410	PD158780		EGFR
	PD 158780 reversibly inhibits auto and transphosphorylation of all four members of the ErbB receptor superfamily: EGFR, ErbB2, ErbB3, and ErbB4 (IC50s: 8μM, 49 nM, 52 nM, and 52 nM in cell assay).		EGFR
T6238	WZ4002		EGFR
	WZ4002 is a mutant-selective EGFR inhibitor for EGFR(L858R) and EGFR(T790M) with IC50 of 2 nM/8 nM.		EGFR
T6824	EAI045		EGFR
	EAI045, an allosteric inhibitor, targets towards drug-resistant EGFR mutants but avoids the wild-type receptor.		EGFR
T17182	TX1-85-1		EGFR
	TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling. TX1-85-1 is an irreversible Her3 inhibitor (IC50: 23 nM). TX1-85-1 is also the first selective Her3 ligand, which forms a cova...		EGFR
T2491	AZ-5104		EGFR
	AZ5104 is a potent EGFR inhibitor.		EGFR
T10534	BI-4020		EGFR
			EGFR
T7819	TAS0728		EGFR , HER
	TAS0728 is a HER2 inhibitor, with antitumor activity		EGFR , HER
T23176	PP 3		Src
	PP 3 is a Negative control for the Src kinase inhibitor PP 2		Src
T16343	NRC-2694		EGFR
	NRC-2694 is an antagonist of the epidermal growth factor receptor (EGFR). It has anti-cancer and anti-proliferative properties.		EGFR
T6008	CNX-2006	CNX 2006,CNX2006	EGFR
	CNX-2006 is a novel irreversible mutant-selective EGFR inhibitor with IC50 of < 20 nM, with very weak inhibition at wild-type EGFR.		EGFR
T11569	HKI-357		EGFR
			EGFR
T9912	Trastuzumab		EGFR
	Trastuzumab is a humanized monoclonal antibody for patients with invasive breast cancers that overexpress HER2. Trastuzumab has been clinically used to treat HER2 Positive Metastatic Breast Cancer and HER2 Positive Gastr...		EGFR
TQ0092	Naquotinib	ASP8273	EGFR
	Naquotinib (ASP8273) (ASP8273) is an orally available, mutant-selective and irreversible EGFR inhibitor; (IC50s: 8-33 nM and 230 nM toward EGFR mutants and EGFR.		EGFR
T6734	WZ8040		EGFR
	WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).		EGFR
T3659	Zorifertinib	AZD3759	EGFR
	Zorifertinib (AZD3759) is an orally active, effective and central nervous system-penetrant EGFR inhibitor. The IC50 values were 0.2, 0.3 and 0.2 nM for EGFR L858R mutant, TK wild-type, and Exon 19Del enzymes, respectivel...		EGFR
T8742	G5-7	JAK2 inhibitor G5-7	Apoptosis , JAK
	JAK2 inhibitor G5-7 (JAK2 inhibitor G5-7) is an orally active JAK2 inhibitor, selectively inhibits JAK2–mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2. G5-7 has the potential for g...		Apoptosis , JAK
T4296	MTX-211	MTX 211	EGFR , PI3K
	MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases.		EGFR , PI3K
T13564	AZ7550		MLK , FAK , EGFR , FLT , Tyrosine Kinases , PYK2 , MNK , IGF-1R , ACK , BTK , ALK , Drug Metabolite
	AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T2034	AG1557	AG-1557,AG 1557	EGFR , HER
	AG1557 (AG-1557) is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase (pIC50: 8.194).		EGFR , HER
T1985	WHI-P154	Jak3 inhibitor ii	Apoptosis , EGFR , VEGFR , JAK , Src
	WHI-P154 (Jak3 inhibitor ii) is a potent JAK3 inhibitor.		Apoptosis , EGFR , VEGFR , JAK , Src
T16369	O-Desmethyl gefitinib		EGFR
	O-Desmethyl gefitinib inhibits EGFR (IC50: 36 nM in subcellular assays). In human plasma, O-Desmethyl gefitinib is an active metabolite of Gefitinib. The formation of O-desmethyl gefitinib is dependent on the CYP2D6 acti...		EGFR
T8431	JCN037		EGFR
	JCN037 is potent, non-covalent and brain-penetrant inhibitor of EGFR(EGFR, p-wtEGFR and pEGFRvⅢ with IC50 of 2.49 nM, 3.95 nM, 4.48 nM , respectively).		EGFR
T3108	CUDC-101	CUDC 101,CUDC101	EGFR , HER , HDAC
	CUDC-101 is a potent inhibitor of HDAC, EGFR and HER2 with IC50s of 4.4, 2.4 and 15.7 nM, respectively.		EGFR , HER , HDAC
T6039	TAK-285	TAK285,TAK 285	EGFR , MEK , HER , Aurora Kinase
	TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. Phase 1.		EGFR , MEK , HER , Aurora Kinase
T70323	Diethanolamine Fusidate
	Diethanolamine Fusidate is a bacteriostatic antibiotic with similar activity and better absorption after oral administration (in animals) than the sodium salt of Fusidic Acid. This product inhibits protein synthesis in p...
T3466	FIIN-3		EGFR , FGFR
	FIIN-3 is an irreversible inhibitor of FGFR.		EGFR , FGFR
T5475	ZD-4190		EGFR , VEGFR
	ZD-4190 is a compound that inhibits both the vascular endothelial growth factor receptor 2 (VEGFR2) and the epidermal growth factor receptor (EGFR) signaling pathways, utilized in cancer treatment.		EGFR , VEGFR
T6124	Mubritinib	TAK-165	EGFR , FGFR , JAK , PDGFR
	Mubritinib (TAK-165) (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM.		EGFR , FGFR , JAK , PDGFR
T8534	Tyrphostin AG 112		EGFR
	Tyrphostin AG 112 is an inhibitor of EGFR phosphorylation.		EGFR
T6932	PD168393		Apoptosis , EGFR , FGFR , IGF-1R , PDGFR , PKC , Autophagy
	PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.
T5437	Gefitinib-based PROTAC 3		EGFR , PROTACs
	Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectivel...		EGFR , PROTACs
T13176	TNO155	Batoprotafib	Phosphatase
	TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11) inhibitor(IC50 : 0.011 µM),with potential antineoplastic activity.		Phosphatase
T3569	SU5214	SU 5214	VEGFR , Tyrosinase
	SU5214 is a modulator of tyrosine kinase signal transduction.		VEGFR , Tyrosinase
T13088	Tarloxotinib bromide	TH-4000	EGFR , HER
			EGFR , HER
T22396	PF-6274484	PF 6274484	EGFR
	PF-6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and ...		EGFR

Compounds

Mutant EGFR inhibitor

T2705

Synonym:

Target: EGFR

EGFR/ErbB-2/ErbB-4 inhibitor-2

T21954

Synonym: EGFR/ErbB2 Inhibitor

Target: EGFR

EGFR-IN-12

T5168

Synonym: EGFR Inhibitor

Target: Apoptosis, EGFR

EGFR/ErbB-2 inhibitor-1

Target: EGFR, c-Met/HGFR

Synonym: Cetuximab (anti-EGFR),C225

Target: EGFR

Olafertinib

TQ0255

Synonym: CK-101,EGFR-IN-3,RX-518

Target: EGFR

Mutated EGFR-IN-1

T16162

Synonym: Osimertinib analog

Target: EGFR

EGFR kinase inhibitor 1

Almonertinib mesylate

Synonym: CNX 2006,CNX2006

Synonym: JAK2 inhibitor G5-7

Target: Apoptosis, JAK

Target: MLK, FAK, EGFR, FLT, Tyrosine Kinases, PYK2, MNK, IGF-1R, ACK, BTK, ALK, Drug Metabolite

AG1557

T2034

Synonym: AG-1557,AG 1557

Target: EGFR, HER

WHI-P154

T1985

Synonym: Jak3 inhibitor ii

Target: Apoptosis, EGFR, VEGFR, JAK, Src

O-Desmethyl gefitinib

Synonym: CUDC 101,CUDC101

Target: EGFR, HER, HDAC

TAK-285

T6039

Synonym: TAK285,TAK 285

Target: EGFR, MEK, HER, Aurora Kinase

Diethanolamine Fusidate

Target: EGFR, VEGFR

Mubritinib

T6124

Synonym: TAK-165

Target: EGFR, FGFR, JAK, PDGFR

Target: Apoptosis, EGFR, FGFR, IGF-1R, PDGFR, PKC, Autophagy

Gefitinib-based PROTAC 3

T5437

Synonym:

Target: EGFR, PROTACs

TNO155

T13176

Synonym: Batoprotafib

Target: VEGFR, Tyrosinase

カタログ番号	製品名	別名	ターゲット
T22974	Methyl 2,5-dihydroxycinnamate		EGFR
	EGF receptor-associated tyrosine kinases inhibitor		EGFR
TN1440	Beta-Hydroxyisovalerylshikonin		EGFR , Tyrosine Kinases , Prostaglandin Receptor , Src , AMPK , Fatty Acid Synthase
	Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor cell lines. Beta-Hydroxyisovalerylshikonin significantly de...
T1181	Gefitinib	ZD1839	EGFR , Tyrosine Kinases , Autophagy
	Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations. Gefitinib has antitumor activity and is used for the treatment of EGFR-mutated non-small-cell...		EGFR , Tyrosine Kinases , Autophagy
T3870	Cyasterone	Cyasteron	Apoptosis , EGFR
	Cyasterone (Cyasteron), a natural EGFR inhibitor, can inhibit the growth of A549 and MGC823 cells, via regulating EGFR signaling pathway, it may be a promising anti-cancer agent. Cyasterone has antifeeding activity.		Apoptosis , EGFR
TL0016	Sulforaphene		Apoptosis , ERK , EGFR , NF-κB
	Sulforaphene is a natural product isolated from radish seeds, exhibits an ED50 against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes cancer cells apoptosis and inhibits migration via inhibiting EG...		Apoptosis , ERK , EGFR , NF-κB
T1431	Khellin	Amicardine,Methafrone,Visammin	EGFR , Others
	Khellin (Methafrone) is a vasodilator that also has bronchodilatory action.		EGFR , Others
T1737	Genistein	NPI 031L	Apoptosis , EGFR , Endogenous Metabolite , Autophagy
	Genistein (NPI 031L) is an isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA TOPOISOMERASES, TYPE II), with antineoplastic and antitumor activities.		Apoptosis , EGFR , Endogenous Metabolite , Autophagy
T0683	Mevastatin	Compactin,ML236B	Apoptosis , Antibacterial , Antibiotic , HMG-CoA Reductase , Autophagy , Lipid
	Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials.
T2995	Chrysophanol	3-Methylchrysazin,Chrysophanic Acid,Turkey Rhubarb	EGFR
	Chrysophanol (Turkey Rhubarb) is an EGFR/mTOR pathway inhibitor, which can be found in rhubarb, and sorrel.		EGFR
T6427	Butein	2’,3,4,4’-tetrahydroxy Chalcone	Apoptosis , EGFR , Others , PDE , Autophagy
	Butein (2’,3,4,4’-tetrahydroxy Chalcone), a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR.		Apoptosis , EGFR , Others , PDE , Autophagy
T4183	Lavendustin A	RG-14355,NSC 678027	EGFR , Tyrosinase
	lavendustin A (RG-14355) is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.		EGFR , Tyrosinase
T2851	Daphnetin	7,8-Dihydroxycoumarin,Daphnetol	EGFR , PKA , PKC , Parasite , Autophagy
	Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-...		EGFR , PKA , PKC , Parasite , Autophagy
T2894	Norcantharidin	Norcantharadine,Endothall anhydride	EGFR , c-Met/HGFR
	Norcantharidin (Norcantharadine) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.		EGFR , c-Met/HGFR
T5656	(±)-Norcantharidin	Endothall anhydride,Norcantharidin	EGFR , c-Met/HGFR
	(±)-Norcantharidin (Endothall anhydride) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers.		EGFR , c-Met/HGFR

天然物製品

Methyl 2,5-dihydroxycinnamate

T22974

Synonym:

Target: EGFR

Beta-Hydroxyisovalerylshikonin

TN1440

Synonym:

Target: EGFR, Tyrosine Kinases, Prostaglandin Receptor, Src, AMPK, Fatty Acid Synthase

Gefitinib

T1181

Synonym: ZD1839

Target: EGFR, Tyrosine Kinases, Autophagy

Cyasterone

T3870

Synonym: Cyasteron

Target: Apoptosis, EGFR

Sulforaphene

TL0016

Synonym:

Target: Apoptosis, ERK, EGFR, NF-κB

Khellin

T1431

Synonym: Amicardine,Methafrone,Visammin

Target: EGFR, Others

Genistein

T1737

Synonym: NPI 031L

Target: Apoptosis, EGFR, Endogenous Metabolite, Autophagy

Mevastatin

T0683

Synonym: Compactin,ML236B

Target: Apoptosis, Antibacterial, Antibiotic, HMG-CoA Reductase, Autophagy, Lipid

Chrysophanol

T2995

Synonym: 3-Methylchrysazin,Chrysophanic Acid,Turkey Rhubarb

Target: EGFR

Butein

T6427

Synonym: 2’,3,4,4’-tetrahydroxy Chalcone

Target: Apoptosis, EGFR, Others, PDE, Autophagy

lavendustin A

T4183

Synonym: RG-14355,NSC 678027

Target: EGFR, Tyrosinase

Daphnetin

T2851

Synonym: 7,8-Dihydroxycoumarin,Daphnetol

Target: EGFR, PKA, PKC, Parasite, Autophagy

Norcantharidin

T2894

Synonym: Norcantharadine,Endothall anhydride

Target: EGFR, c-Met/HGFR

(±)-Norcantharidin

T5656

Synonym: Endothall anhydride,Norcantharidin

Target: EGFR, c-Met/HGFR

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-01710	IkB alpha/NFKBIA Protein, Human, Recombinant (His)	Human	E. coli
	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkB alpha, NFKBIA, or IKBA), is a member of the NF-kappa-B inhibitor family that function to inhibit the NF-kB transcription factor. NF...

IkB alpha/NFKBIA Protein, Human, Recombinant (His)

TMPY-01710

Species: Human

Expression System: E. coli

カタログ番号	製品名
L9410	Covalent Inhibitor Library	1920 compounds
	A unique collection of 1920 covalent Inhibitors and other molecules with common warheads like chloroacetyl，2-Chloropropionyl，Acryloyl，sulfonyl fluoride, alkyne，acrylamide, ketocarbonyl，disulfide bond, etc.
L1610	FDA-Approved Kinase Inhibitor Library	263 compounds
	A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
L1600	Kinase Inhibitor Library	2720 compounds
	A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;

ライブラリー

Covalent Inhibitor Library

L9410

Compounds: 1920

FDA-Approved Kinase Inhibitor Library

L1610

Compounds: 263

Kinase Inhibitor Library

L1600

Compounds: 2720